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DBCO-NHS ester

CAS No. 1353016-71-3

DBCO-NHS ester ( DBCO NHS ester )

Catalog No. M11436 CAS No. 1353016-71-3

An amine-reactive NHS ester that provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as that of protein, peptide, or small molecule amine.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DBCO-NHS ester
  • Note
    Research use only, not for human use.
  • Brief Description
    An amine-reactive NHS ester that provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as that of protein, peptide, or small molecule amine.
  • Description
    An amine-reactive NHS ester that provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as that of protein, peptide, or small molecule amine; A click chemistry tool used to conjugate DBCO-PEG4-MMAF to the introduced non-natural amino acid pAMF using a noncleavable linker.
  • Synonyms
    DBCO NHS ester
  • Pathway
    Antibody Drug Conjugates (ADC)
  • Target
    ADCs Linker/Click Chemistry
  • Recptor
    ADCs Linker/Click Chemistry
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1353016-71-3
  • Formula Weight
    430.45
  • Molecular Formula
    C25H22N2O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(CCC(ON1C(CCC1=O)=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4
  • Chemical Name
    Dibenz[b,f]azocine-5(6H)-butanoic acid,11,12-didehydro-γ-oxo-,2,5-dioxo-1-pyrrolidinyl es

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Currier NV, et al. Mol Cancer Ther. 2016 Jun;15(6):1291-300.
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